The intestine is an important defence barrier for the body, the gastrointestinal tract (GI) gathers 2/3 of the overall immune system thanks to a complex microbiological ecosystem, comprising over 400 bacterial species. The most important effects of GI microflora is to protect the host from infections and pathogens development, promoting the establishment and the activity of immunological tissues. It is very important to maintain intestinal ecosystem or to restore the balance after an antibiotic therapy in order to prevent, for instance, the Helicobacter pylori infection.
Helicobacter pylori is the most important causative agent of chronic gastritis, also known as “nonspecific” and it is responsible for more than 90-95% of duodenal ulcers, too. The disease causing relationship between the ulcers and the infection is supported by studies, which have shown that by the eradication of the bacteria the signs of inflammation may be initially decreased and later disappeared.
Propolis: scientific studies
The activity of Purified Polyphenols from propolis M.E.D.® was investigated against Lactobacilli spp. (L. plantarum, L. paracasei, L. gasseri, L. acidophilus) that is part of gastrointestinal normal flora. The in-vitro studies have shown no activity of Purified Polyphenols from propolis M.E.D.® towards these species, promising a good interaction between the two elements.
Many studies show that propolis possess gastric cytoprotective and hepatoprotective effects. The exact mechanism of Propolis effect on Helicobacter pylori is still not clear even analysing in vitro activity.