Propolis has been used since ancient times as folk remedy. Nowadays in literature there are hundreds of studies supporting the healthy properties of Propolis, such as antibacterial, antiviral, antifungal, antiulcer, antioxidant, antiradiation, hepatoprotective, antitumor, antimutagenic, anti-angiogenic, cyto- and chemopreventive, anti-inflammatory, wound healing, immunomodulating (immunostimulating and immunosuppressive in autoimmune diseases), cardioprotective (antimyocardial injury, antithrombogenic, antihypertensive, antiarrhythmic), local anesthetic, regenerative (cartilaginous and bone tissue, dental pulp) and food preservative activities (Fidalgo et al., 2011; Mathivanan et al., 2013; Lofty, 2006; Marcucci, 1995; Burdock, 1998; Castaldo et al., 2002 Sforcin et al. 2001; 2007; Banskota et al. 2001; Bankova, 2005c; 2014). It was recently demonstrated that the combination of polyphenolic species is essential for the biological activity of propolis (Boisard et al., 2015).

We have evaluated the effect of our M.E.D.® Propolis in different experimental models to determine its antimicrobial and anti-inflammatory activities. It has been demonstrated its distinctive activities against a large panel of microorganisms and its capability to reduce inflammation. Additional studies are now in progress to verify the effect of Characterized Polyphenols Complex  as a natural preservative and biological pesticide.

This wide spectrum of effects and the flexibility to adapt to any formulation makes the Characterized Polyphenols Complex obtained with Multi Dynamic Extraction a potential candidate for the development of several products in many areas: from Human Health to Veterinary, from Agriculture to Food and Cosmetics…

Antioxidant and Antinflammatory activity

One of the most studied properties of propolis is its antioxidant capacity (Kurek-Gorecka et al., 2013). The main compounds responsible for this activity are polyphenols, which show higher radical scavenging activity than most common antioxidants, such as vitamin C and vitamin E (Banskota et al., 2000). Antioxidant activity is a very important topic since many syndromes are linked to an imbalance between the antioxidant defense system and the production of free radicals (Favier 1997).

As anti-inflammatory agent, propolis has been shown to inhibit the synthesis of prostaglandins, activate the thymus, help the immune system by promoting phagocytic activity, stimulate cellular immunity and improve curative effects in epithelial tissues (Casaroto et al., 2010).

Thanks the studies conducted at University of Pavia and published by Zaccaria, Curti et al. 2017, 2019 using standardized M.E.D.® propolis extracts, it was possible to clarify in vitro the intracellular anti-inflammatory and antioxidant mechanisms, in vivo the antioxidant activity and the bioavailability, and in vitro the antibacterial activity.

Antimicrobial activity

Since ancient times, propolis has been used for its antimicrobial properties.

Nowadays, due to the increase of antibiotic resistance and thanks to the increased attention of scientific community and consumers on natural products, propolis is considered for new applications to reduce the use of antibiotic drugs.

The most known and studied activity of propolis is the antibacterial one. Using a panel of many microorganisms from clinical isolates and ATCC library, different species and strains, both sensitive and resistant to antibiotics, researchers from University of Pavia and Modena (Italy) evaluated the antibacterial activity of propolis M.E.D.® Propolis. The results suggested that propolis was active against many different bacterial and fungi, especially the ones that causes skin, respiratory, vaginal and gastrointestinal infections.