Upper respiratory tract infections involve generally nose, paranasal sinuses, pharynx and larynx causing sore throat, cough, nasal discharge or common cold. Pharyngitis, laryngitis, rhinitis, sinusitis, otitis media are inflammatory status of upper respiratory tract mucous membranes. They give burning sensations, difficulty in swallowing, pain, sneezing and negging feeling stuffy nose. These conditions are usually short and mild. However, if neglected, they can lead to chronic inflammation or lower respiratory tract infections.

  • Rhinitis is characterized by inflammation of the nasal mucosa due to infectious (viruses, bacteria), anatomical (excessive sensitivity and/or number of capillaries in the nasal mucosa) or irritant factors. The main symptom of rhinitis is rhinorrhoea, namely the nasal discharge (due to hyper secretion of mucus by the inflamed mucosa), which is accompanied by sneezing and a nagging feeling stuffy nose.
  • Otitis  is an inflammatory process of acute or chronic type, related to ears and caused by pathogenic organisms of various types that can be localized in correspondence of ears both directly and indirectly. Depending on the part of the ear affected by the inflammation, otitis are distinguished: external, middle and inner (labyrinthitis).

It was studied the effect of Propolis on sneezing and nasal mucosa irritation in rhinitis and it was concluded that Propolis may be effective in relieving symptoms in particular through the inhibition of histamine. An inflammation induced in epithelial cells of medium ear can be inhibited by Propolis through the inhibition of the expression of pro-inflammatory cytokines such as TNF-alpha and COX – 2. Moreover, Propolis has antioxidant effects, which reduce the need of expression endogenous superoxide dismutase.


B Natural Propolis Activity

We have tested our Propolis M.E.D.®  for its antimicrobial activity against a panel of Gram-positive and Gram-negative bacteria. We have focused on microorganisms that normally occur in case of irritation and infections of the mouth and upper airways.  Moreover, we have decided to test the activity of our Characterized Polyphenols Complex®  against a group of Staphylococci and Streptococci resistant to antibiotics called the beta-lactams (which include penicillins and cephalosporins).